Description
PE-22-28 is a seven-residue fragment of spadin, itself derived from the protein sortilin, acting as a blocker of the TREK-1 potassium channel.
TREK-1 inhibition is a candidate antidepressant mechanism distinct from monoamine pharmacology, and this fragment is the optimized research probe for that channel in published rodent models of mood and neurogenesis.
Format & handling
Supplied as a lyophilized powder in a sealed, batch-stamped vial. Store sealed at −20 °C protected from light. For laboratory work, reconstitute with bacteriostatic water shortly before use and refrigerate any working solution at 2–8 °C.
For laboratory research use only — not for human or veterinary use. The summary above describes published research for scientific context and makes no claims about this product.
